Data Sheet

MSDS

GSK481 [CAS 1622849-58-4]

CAS No:	1622849-58-4
Applications:	COVID-19-immunoregulation
MW:	377.39
Formula:	C₂₁H₁₉N₃O₄
SMILES:	O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@H]3COC4=CC=CC=C4N(C)C3=O
Purity:	98.57
Description:	GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC50 of 1.3 nM, which inhibits Ser166 phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC50 of 10 nM[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only