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Ordering Details

Cat Number:BNCB2557-500
Size:500uL
Concentration:0.1 mg/mL
Price:£580.00
Quantity:
Shipping:£12.00

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Data Sheet
MSDS

 

IgM [Immunoglobulin Mu Heavy Chain] [B-Cell Marker] [IGHM/2557R] Biotin, Rabbit Monoclonal Antibody

Partner: Biotium

Applications:IHC(p)
Isotype:Rabbit IgG
Purification:PBS, 0.1% BSA, 0.05% azide
Conjugation:Biotin
Description:Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant. Primary antibodies are available purified, or with a selection of fluorescent CF� Dyes and other labels. CF� Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF�405S and CF�405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Further Information:IHC, FFPE (verified)
Shipping Conditions:Ship at ambient
Storage:Store at 4 C
Usage:Research Use Only

 

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