ZAP70 [ZAP70/528 + 2F3.2] CF555, Mouse Monoclonal Antibody
Partner: Biotium
| Applications: | IHC(p) |
| Isotype: | Mouse |
| Purification: | PBS, 0.1% BSA, 0.05% azide |
| Conjugation: | CF555 |
| Description: | ZAP70 is a 70 kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.Primary antibodies are available purified, or with a selection of fluorescent CF� Dyes and other labels. CF� Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF�405S and CF�405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. |
| Further Information: | IHC, FFPE (verified) |
| Shipping Conditions: | Ship at ambient |
| Storage: | Store at 4 C |
| Usage: | Research Use Only |
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