| Applications: | WB |
| Species Reactivity: | Human, Zebrafish |
| Purification: | Purified Rabbit Polyclonal Antibody |
| Description: | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity). |
| Further Information: | This stk3(36kDa subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-252 amino acids from the Central region of stk3(36kDa subunit). |
| Synonym: | Serine/threonine-protein kinase 3, Serine/threonine-protein kinase 3 36kDa subunit, MST2/N, Serine/threonine-protein kinase 3 20kDa subunit, MST2/C, stk3 |
| Ascension Number: | Q7ZUQ3 |
| NCBI EntrezGene: | 324125 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
