| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 38.4kDa (342aa) |
| Purity: | > 90% by SDS - PAGE |
| Description: | Activin RIA, also known as Activin receptor type-1, is a member of TGF-beta serine/threonine kinase receptor family. It forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. This protein is involved for left-right pattern formation during embryogenesis. Also, it is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. It has been connected to Fibrodysplasia Ossificans Progressiva, a disease characterized by the formation of heterotopic bone throughout the body. Recombinant Human Activin RIA, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF HLE<LEPKSCD KTHTCPPCPA> <PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG> <VEVHNAKTKP <REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL> <PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT> <VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH> |
| Synonym: | ACVR1, ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI, Activin receptor type I, Activin receptor-like kinase 2, ACTR-I, ALK-2, TSR-I, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I |
| Ascension Number: | Q04771 |
| NCBI EntrezGene: | NP_001096 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
