| Applications: | SDS-PAGE |
| Species Reactivity: | Mouse |
| MW: | 24.7kDa (226aa) |
| Purity: | > 90% by SDS - PAGE |
| Description: | B7H3, also known as CD276 antigen, is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. This protein plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. It induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells. Recombinant mouse B7H3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: VEVQVSEDPV VALVDTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA YSNRTALFPD LLVQGNASLR LQRVRVTDEG SYTCFVSIQD FDSAAVSLQV AAPYSKPSMT LEPNKDLRPG NMVTITCSSY QGYPEAEVFW KDGQGVPLTG NVTTSQMANE RGLFDVHSVL RVVLGANGTY SCLVRNPVLQ QDAHGSVTIT GQPLTFPPEA <HHHHHH> |
| Synonym: | CD276 antigen, Cd276, 6030411F23Rik, AU016588, B7h3, B7RP-2, B7 homolog 3, B7-H3 |
| Ascension Number: | Q8VE98 |
| NCBI EntrezGene: | NP_598744 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
