| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 55.3kDa (485aa);;50-70kDa (SDS-PAGE under reducing conditions) |
| Purity: | > 90% by SDS - PAGE |
| Description: | CD72, also known as B-cell differentiation antigen CD72, is a type II transmembrane glycoprotein carrying a C-type lectin domain. It plays a role in immune system regulation of animals and expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells as a homodimer. Also, this protein associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP1. It binding to Semaphorin 4D induces cytokine production by monocytes and dendritic cells, inhibits SCF R/ckit induced mast cell proliferation and activation, and inhibits the cytolytic activity of NK cells. Moreover, BCR signaling enhances phosphorylation of CD72 and its recruitment of SHP-1. Recombinant human CD72, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: <ADP>RYLQVSQ QLQQTNRVLE VTNSSLRQQL RLKITQLGQS AEDLQGSRRE LAQSQEALQV EQRAHQAAEG QLQACQADRQ KTKETLQSEE QQRRALEQKL SNMENRLKPF FTCGSADTCC PSGWIMHQKS CFYISLTSKN WQESQKQCET LSSKLATFSE IYPQSHSYYF LNSLLPNGGS GNSYWTGLSS NKDWKLTDDT QRTRTYAQSS KCNKVHKTWS WWTLESESCR SSLPYICEMT AFRFPD<LEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH> <EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL> <PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE> <NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH> <HHHHH> |
| Synonym: | CD72, CD72b, LYB2, B-cell differentiation antigen CD72, Lyb-2, CD_antigen: CD72 |
| Ascension Number: | P21854 |
| NCBI EntrezGene: | NP_001773 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
