| Applications: | Bioactivity, SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 53.3kDa (468aa);;50-70KDa (SDS-PAGE under reducing conditions.) |
| Purity: | > 90% by SDS - PAGE |
| Description: | Vitronectin, also known VTN, is a member of the pexin family. It is a cell adhesion and spreading factor found in serum and tissues. This protein interacts with glycosaminoglycans and proteoglycans and is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. It also contains endogenous cleavage sites such as elastase, thrombin and plasmin. This protein binds multiple ligands, including the soluble vitronectin receptor which affects multi-function. Therefore, it is involved in hemostasis, cell migration, as well as tumor malignancy. Recombinant human Vitronectin protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: ADPDQESCKG RCTEGFNVDK KCQCDELCSY YQSCCTDYTA ECKPQVTRGD VFTMPEDEYT VYDDGEEKNN ATVHEQVGGP SLTSDLQAQS KGNPEQTPVL KPEEEAPAPE VGASKPEGID SRPETLHPGR PQPPAEEELC SGKPFDAFTD LKNGSLFAFR GQYCYELDEK AVRPGYPKLI RDVWGIEGPI DAAFTRINCQ GKTYLFKGSQ YWRFEDGVLD PDYPRNISDG FDGIPDNVDA ALALPAHSYS GRERVYFFKG KQYWEYQFQH QPSQEECEGS SLSAVFEHFA MMQRDSWEDI FELLFWGRTS AGTRQPQFIS RDWHGVPGQV DAAMAGRIYI SGMAPRPSLA KKQRFRHRNR KGYRSQRGHS RGRNQNSRRP SRATWLSLFS SEESNLGANN YDDYRMDWLV PATCEPIQSV FFFSGDKYYR VNLRTRRVDT VDPPYPRSIA QYWLGCPAPG HLHHHHHH |
| Synonym: | Vitronectin, VTN, V75, VN, VNT |
| Ascension Number: | P04004 |
| NCBI EntrezGene: | NP_000629 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
