| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 53.7kDa (480aa);;50-70kDa (SDS-PAGE under reducing conditions.) |
| Purity: | > 90% by SDS - PAGE |
| Description: | ICOSLG, also known as ICOS ligand isoform a, is a number of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. This protein is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells. Its dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. Recombinant human ICOSLG, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: ADPDTQEKEV RAMVGSDVEL SCACPEGSRF DLNDVYVYWQ TSESKTVVTY HIPQNSSLEN VDSRYRNRAL MSPAGMLRGD FSLRLFNVTP QDEQKFHCLV LSQSLGFQEV LSVEVTLHVA ANFSVPVVSA PHSPSQDELT FTCTSINGYP RPNVYWINKT DNSLLDQALQ NDTVFLNMRG LYDVVSVLRI ARTPSVNIGC CIENVLLQQN LTVGSQTGND IGERDKITEN PVSTGEKNAA TLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH |
| Synonym: | ICOS ligand isoform a, ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS |
| Ascension Number: | O75144 |
| NCBI EntrezGene: | NP_056074 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
