| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 7.2kDa (66aa);;18-28KDa (SDS-PAGE under reducing conditions.) |
| Purity: | > 95% by SDS - PAGE |
| Description: | GYPC, also known as glycophorin-C isoform 1, is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. Recombinant human GYPC protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: ADPMWSTRSP NSTAWPLSLE PDPGMASAST TMHTTTIAEP DPGMSGWPDG RMETSTPTIM HHHHHH |
| Synonym: | Glycophorin-C isoform 1, GYPC, CD236, CD236R, GE, GPC, GPD, GYPD, PAS-2, PAS-2 |
| Ascension Number: | P04921 |
| NCBI EntrezGene: | NP_002092 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
