| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 37.3kDa (338aa);;40-57KDa (SDS-PAGE under reducing conditions.) |
| Purity: | > 90% by SDS - PAGE |
| Description: | DKK3, also known as dickkopf WNT signaling pathway inhibitor 3, is a member of the DKK protein family including Dkk-1, 2, 3 and 4. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Recombinant human DKK3 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: ADPAPAPTAT SAPVKPGPAL SYPQEEATLN EMFREVEELM EDTQHKLRSA VEEMEAEEAA AKASSEVNLA NLPPSYHNET NTDTKVGNNT IHVHREIHKI TNNQTGQMVF SETVITSVGD EEGRRSHECI IDEDCGPSMY CQFASFQYTC QPCRGQRMLC TRDSECCGDQ LCVWGHCTKM ATRGSNGTIC DNQRDCQPGL CCAFQRGLLF PVCTPLPVEG ELCHDPASRL LDLITWELEP DGALDRCPCA SGLLCQPHSH SLVYVCKPTF VGSRDQDGEI LLPREVPDEY EVGSFMEEVR QELEDLERSL TEEMALREPA AAAAALLGGE EIHHHHHH |
| Synonym: | dickkopf WNT signaling pathway inhibitor 3, DKK3, RIG, REIC |
| Ascension Number: | Q9UBP4 |
| NCBI EntrezGene: | NP_001018067 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
