| Applications: | SDS-PAGE |
| Species Reactivity: | Mouse |
| MW: | 10.4kDa (91aa) confirmed by MALDI-TOF |
| Purity: | > 95% by SDS - PAGE |
| Description: | Cxcl12 also known as stromal cell-derived factor 1 isoform alpha. This protein acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. This protein inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Cxcl12 protein plays a protective role after myocardial infarction. It induces down-regulation and internalization of ACKR3 expressed in various cells. Recombinant mouse Cxcl12, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques |
| Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MGSKPVSLSY RCPCRFFESH IARANVKHLK ILNTPNCALQ IVARLKNNNR QVCIDPKLKW IQEYLEKALN K |
| Synonym: | Stromal cell-derived factor 1 isoform alpha, Pbsf, Scyb12, Sdf1, Tlsf, Tpar1 |
| Ascension Number: | P40224 |
| NCBI EntrezGene: | NP_068350 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
