| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 11.5 kDa (106aa) confirmed by MALDI-TOF |
| Purity: | > 80% by SDS - PAGE |
| Description: | PDE6H is the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). Recombinant human PDE6H protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSDNTTL PAPASNQGPT TPRKGPPKFK QRQTRQFKSK PPKKGVKGFG DDIPGMEGLG TDITVICPWE AFSHLELHEL AQFGII |
| Synonym: | Retinal cone rhodopsin-sensitive cGMP 3'5'-cyclic phosphodiesterase subunit gamma, Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ACHM6, RCD3 |
| Ascension Number: | Q13956 |
| NCBI EntrezGene: | NP_006196 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
