| Applications: | SDS-PAGE, Denatured |
| Species Reactivity: | Human |
| MW: | 26.3 kDa (234aa) |
| Purity: | > 85% by SDS - PAGE |
| Description: | DuSP26 inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. This protein inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. DuSP26 can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Recombinant human DuSP26 protein, fused to His-tag at N-terminus, was expressed in E. coli. |
| Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA |
| Synonym: | Dual specificity protein phosphatase 26, Dual specificity protein phosphatase 26, Dual specificity phosphatase 26 (putative), DuSP24, LDP-4, MKP8, NATA1, SKRP3 |
| Ascension Number: | Q9BV47 |
| NCBI EntrezGene: | NP_076930 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
