| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 25.9kDa (232aa) confirmed by MALDI-TOF |
| Purity: | > 85% by SDS - PAGE |
| Description: | DTD1 hydrolyzes D-tyrosyl-tRNA (Tyr) into D-tyrosine and free tRNA (Tyr). It could be a defense mechanism against a harmful effect of D-tyrosine. DTD1 may be a risk factor for aspirin-intolerant asthma (AIA) by catalyzing the hydrolysis of D-tryptophan and interacting with the tyrosyl-tRNA synthetase (tyrRS) enzyme, which promotes a pro-inflammatory phenotype. This protein is localize to the DuE (DNA unwinding element ) s of active replication origins. Recombinant human DTD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MGSMKAVVQR VTRASVTVGG EQISAIGRGI CVLLGISLED TQKELEHMVR KILNLRVFED ESGKHWSKSV MDKQYEILCV SQFTLQCVLK GNKPDFHLAM PTEQAEGFYN SFLEQLRKTY RPELIKDGKF GAYMQVHIQN DGPVTIELES PAPGTATSDP KQLSKLEKQQ QRKEKTRAKG PSESSKERNT PRKEDRSASS GAEGDVSSER EP |
| Synonym: | D-tyrosyl-tRNA deacylase 1, bA379J5.3, bA555E18.1, C20orf88, DuEB, HARS2, pqn-68 |
| Ascension Number: | Q8TEA8 |
| NCBI EntrezGene: | NP_543010 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
