| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 34.6 kDa (295aa), confirmed by MALDI-TOF |
| Purity: | > 85% by SDS - PAGE |
| Description: | Autophagy protein 5, also known as ATG5, belongs to the autophagy-related (ATG) genes family. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. ATG5 protein is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Recombinant human ATG5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLPRVSYLTLVTD KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNITVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ KLFRPVAADG QLHTLGDLLKEVCPSAIDPE DGEKKNQVMI HGIEPMLETP LQWLSEHLSY PDNFLHISII PQPTD |
| Synonym: | Autophagy protein 5, APG5, APG5-LIKE, APG5L, ASP, hAPG5 |
| Ascension Number: | Q9H1Y0 |
| NCBI EntrezGene: | NP_004840 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
