| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 27.5kDa (257aa) confirmed by MALDI-TOF |
| Purity: | > 95% by SDS - PAGE |
| Description: | CBR4 belongs to the short-chain dehydrogenase/reductase family. The formation of heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity for o- and p-quinones. It plays a role in biosynthesis of fatty acids in mitochondria and has broad substrate specificity and reduces 9, 10-phenanthrenequinone, 1, 4-benzoquinone and various other o-quinones and p-quinones (in vitro). Recombinant human CBR4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MDKVCAVFGG SRGIGRAVAQ LMARKGYRLA VIARNLEGAK AAAGDLGGDH LAFSCDVAKE HDVQNTFEEM EKHLGRVNFL VNAAGINRDG LLVRTKTEDM VSQLHTNLLG SMLTCKAAMR TMIQQQGGSI VNVGSIVGLK GNSGQSVYSA SKGGLVGFSR ALAKEVARKK IRVNVVAPGF VHTDMTKDLK EEHLKKNIPL GRFGETIEVA HAVVFLLESP YITGHVLVVD GGLQLIL |
| Synonym: | Carbonyl reductase family member 4, Carbonyl reductase family member 4, Quinone reductase CBR4, 3-oxoacyl-[acyl-carrier-protein] reductase |
| Ascension Number: | Q8N4T8 |
| NCBI EntrezGene: | AAH21973 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
