| Applications: | Enzyme Activity, SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 28.8kDa (255aa), confirmed by MALDI-TOF. |
| Purity: | > 90% by SDS - PAGE |
| Description: | PRDX4 is an antioxidant enzyme and belongs to the peroxiredoxin (Prdx, Prx, or TrxPx) family. This protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein regulates the of the transcription factor NF-kappaB in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. The ubiquitously expressed peroxiredoxins have also been shown to play a role in apoptosis and cell differentiation. Recombinant human PRDX4, fused to His-tag at N-terminus, was expressed in E. coli and purified by conventional chromatography techniques. |
| Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MWETEERPRT REEECHFYAG GQVYPGEASR VSVADHSLHL SKAKISKPAP YWEGTAVIDG EFKELKLTDY RGKYLVFFFY PLDFTFVCPT EIIAFGDRLE EFRSINTEVV ACSVDSQFTH LAWINTPRRQ GGLGPIRIPL LSDLTHQISK DYGVYLEDSG HTLRGLFIID DKGILRQITL NDLPVGRSVD ETLRLVQAFQ YTDKHGEVCP AGWKPGSETI IPDPAGKLKY FDKLN |
| Synonym: | peroxiredoxin 4, PRX-4, AOE37-2, PRDX4, peroxiredoxin 4 Antioxidant enzyme 372, Antioxidant enzyme AOE372, AOE37 2, AOE372, EC 1.11.1.15, Peroxiredoxin4, PRDX 4, PRX 4, Prx IV, PRX4, PrxIV, Thioredoxin dependent peroxide reductase A0372, Thioredoxin peroxidase, Thioredoxin Peroxidase (Antioxidant Enzyme), Thioredoxin peroxidase AO372, TRANK. |
| Ascension Number: | Q13162 |
| NCBI EntrezGene: | NP_006397 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
