Ordering Details
Cat Number:	ATGA0400-50ul
Size:	50uL
Concentration:	1 mg/mL
Price:	£123.00
Quantity:
Shipping:	£12.00

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MSDS

ADSL [AT16C10], Mouse Monoclonal Antibody

Partner: NKMax Bio (ATGen)

Applications:	ELISA, WB, FACS, ICC/IF
Species Reactivity:	Human
Isotype:	Mouse IgG1 kappa
Immunogen:	Recombinant human ADSL(1-484aa) purified from E. coli
Purification:	By protein-A affinity chromatography
Conjugation:	Unconjugated
Description:	Adenylosuccinate lyase, also known as ADSL, is an enzyme that converts adenylosuccinate to AMP and fumarate as part of the purine nucleotide cycle. Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency). ADSL deficiency is an autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado).
Further Information:	The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Synonym:	Adenylosuccinate lyase, AMPS, ASASE, ASL
Ascension Number:	P30566
NCBI EntrezGene:	NP_000017
Shipping Conditions:	Ship on cold packs
Storage:	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Usage:	Research use only

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The Recombinant Human ADSL (20ng) and Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human ADSL antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.Lane 1. : Recombinant Protein Lane 2. : HeLa cell lysate Lane 3. : 293T cell lysate Lane 4. : Jurkat cell lysate Lane 5. : HepG2 cell lysate Lane 6. : A549 cell lysate Lane 7. : MCF7 cell lysate

ICC/IF analysis of ADSL in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human ADSL antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).