| Applications: | IHC-P, WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Purified Rabbit Polyclonal Antibody |
| Description: | ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis. |
| Further Information: | This Activin A Receptor Type IC (ACVR1C) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human Activin A Receptor Type IC (ACVR1C). |
| Synonym: | Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ACVR1C (<a href=http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=18123 target=_blank>HGNC:18123</a>) |
| Ascension Number: | Q8NER5 |
| NCBI EntrezGene: | 130399 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
