| Applications: | IHC-P |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Purified Rabbit Polyclonal Antibody |
| Description: | MLLT2 is involved in acute leukemias through a chromosomal translocation t(4;11)(q21;q23) that involves mllt2 and mll/hrx. AF-4 (MLLT2), AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis. |
| Further Information: | This AF4 (MLLT2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1181~1210 amino acids from the C-terminal region of human MLLT2. |
| Synonym: | AF4/FMR2 family member 1, ALL1-fused gene from chromosome 4 protein, Protein AF-4, Protein FEL, Proto-oncogene AF4, AFF1, AF4, FEL, MLLT2, PBM1 |
| Ascension Number: | P51825 |
| NCBI EntrezGene: | 4299 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
