| Applications: | DB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a polypeptide hormone precursor thatundergoes extensive, tissue-specific, post-translational processingvia cleavage by subtilisin-like enzymes known as prohormoneconvertases. There are eight potential cleavage sites within thepolypeptide precursor and, depending on tissue type and theavailable convertases, processing may yield as many as tenbiologically active peptides involved in diverse cellularfunctions. The encoded protein is synthesized mainly incorticotroph cells of the anterior pituitary where four cleavagesites are used; adrenocorticotrophin, essential for normalsteroidogenesis and the maintenance of normal adrenal weight, andlipotropin beta are the major end products. In other tissues,including the hypothalamus, placenta, and epithelium, all cleavagesites may be used, giving rise to peptides with roles in pain andenergy homeostasis, melanocyte stimulation, and immune modulation.These include several distinct melanotropins, lipotropins, andendorphins that are contained within the adrenocorticotrophin andbeta-lipotropin peptides. Mutations in this gene have beenassociated with early onset obesity, adrenal insufficiency, and redhair pigmentation. Alternatively spliced transcript variantsencoding the same protein have been described. [provided byRefSeq]. |
| Further Information: | This ACTH Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S168 of human ACTH. |
| Synonym: | Pro-opiomelanocortin, POMC, Corticotropin-lipotropin, NPP, Melanotropin gamma, Gamma-MSH, Potential peptide, Corticotropin, Adrenocorticotropic hormone, ACTH, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin, POMC |
| Ascension Number: | P01189 |
| NCBI EntrezGene: | 5443 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
