Ordering Details
Cat Number:	AP2766a
Size:	400uL
Price:	£304.00
Quantity:
Shipping:	£12.00

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Data Sheet

MSDS

MBP [Y203] [RB15523], Rabbit Polyclonal Antibody

Partner: Abcepta, Inc.

Applications:	WB
Species Reactivity:	Human
Isotype:	Rabbit IgG
Purification:	Affinity Purified Rabbit Polyclonal Antibody
Description:	MBP is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Further Information:	This MBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-209 amino acids from human MBP.
Synonym:	Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP
Ascension Number:	P02686
NCBI EntrezGene:	4155
Shipping Conditions:	Ship on cold packs
Storage:	Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:	Research use only

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Anti MBP Antibody (Y203) at 1:16000 dilution + human cerebellum lysateLysates/proteins at 20 �g per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 33 kDaBlocking/Dilution buffer: 5% NFDM/TBST.