| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Purified Rabbit Polyclonal Antibody |
| Description: | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |
| Further Information: | This ZNF423 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 864-897 amino acids from the Central region of human ZNF423. |
| Synonym: | Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, Smad- and Olf-interacting zinc finger protein, ZNF423, KIAA0760, NPHP14, OAZ |
| Ascension Number: | Q2M1K9 |
| NCBI EntrezGene: | 23090 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
