| Applications: | WB |
| Species Reactivity: | Human, Mouse |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes coagulation factor XIII B subunit.Coagulation factor XIII is the last zymogen to become activated inthe blood coagulation cascade. Plasma factor XIII is aheterotetramer composed of 2 A subunits and 2 B subunits. The Asubunits have catalytic function, and the B subunits do not haveenzymatic activity and may serve as a plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits, which areidentical to those of plasma origin. Upon activation by thecleavage of the activation peptide by thrombin and in the presenceof calcium ion, the plasma factor XIII dissociates its B subunitsand yields the same active enzyme, factor XIIIa, as platelet factorXIII. This enzyme acts as a transglutaminase to catalyze theformation of gamma-glutamyl-epsilon-lysine crosslinking betweenfibrin molecules, thus stabilizing the fibrin clot. Factor XIIIdeficiency is classified into two categories: type I deficiency,characterized by the lack of both the A and B subunits; and type IIdeficiency, characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency, defectivewound healing, and habitual abortion. |
| Further Information: | This F13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the N-terminal region of human F13B. |
| Synonym: | Coagulation factor XIII B chain, Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain, F13B |
| Ascension Number: | P05160 |
| NCBI EntrezGene: | 2165 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
