| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. This protein is expressedby T cells and macrophages, and is known to be an importantco-receptor for macrophage-tropic virus, including HIV, to enterhost cells. Defective alleles of this gene have been associatedwith the HIV infection resistance. The ligands of this receptorinclude monocyte chemoattractant protein 2 (MCP-2), macrophageinflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatoryprotein 1 beta (MIP-1 beta) and regulated on activation normal Texpressed and secreted protein (RANTES). Expression of this genewas also detected in a promyeloblastic cell line, suggesting thatthis protein may play a role in granulocyte lineage proliferationand differentiation. This gene is located at the chemokine receptorgene cluster region. Two transcript variants encoding the sameprotein have been found for this gene. |
| Further Information: | This CCR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-177 amino acids from the Central region of human CCR5. |
| Synonym: | C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5, CHEMR13, HIV-1 fusion coreceptor, CD195, CCR5, CMKBR5 |
| Ascension Number: | P51681 |
| NCBI EntrezGene: | 1234 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
