| Applications: | WB |
| Species Reactivity: | Mouse |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a tumor suppressor protein that acts asan antagonist of the Wnt signaling pathway. It is also involved inother processes including cell migration and adhesion,transcriptional activation, and apoptosis. Defects in this genecause familial adenomatous polyposis (FAP), an autosomal dominantpre-malignant disease that usually progresses to malignancy.Disease-associated mutations tend to be clustered in a small regiondesignated the mutation cluster region (MCR) and result in atruncated protein product. |
| Further Information: | This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC. |
| Synonym: | Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25 |
| Ascension Number: | P25054 |
| NCBI EntrezGene: | 324 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
