| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a 105 kD protein which can undergocotranslational processing by the 26S proteasome to produce a 50 kDprotein. The 105 kD protein is a Rel protein-specific transcriptioninhibitor and the 50 kD protein is a DNA binding subunit of theNF-kappa-B (NFKB) protein complex. NFKB is a transcriptionregulator that is activated by various intra- and extra-cellularstimuli such as cytokines, oxidant-free radicals, ultravioletirradiation, and bacterial or viral products. Activated NFKBtranslocates into the nucleus and stimulates the expression ofgenes involved in a wide variety of biological functions.Inappropriate activation of NFKB has been associated with a numberof inflammatory diseases while persistent inhibition of NFKB leadsto inappropriate immune cell development or delayed cell growth.Two transcript variants encoding different isoforms have been foundfor this gene. |
| Further Information: | This NFKB(p105) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-937 amino acids from the C-terminal region of human NFKB(p105). |
| Synonym: | Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1 |
| Ascension Number: | P19838 |
| NCBI EntrezGene: | 4790 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
