| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene product constitutes one of the subunits of themultisubunit particle called exosome, which mediates mRNAdegradation. The composition of human exosome is similar to itsyeast counterpart. This protein is homologous to the yeast Mtr3protein. Its exact function is not known, however, it has beenshown using a cell-free RNA decay system that the exosome isrequired for rapid degradation of unstable mRNAs containing AU-richelements (AREs), but not for poly(A) shortening. The exosome doesnot recognize ARE-containing mRNAs on its own, but requiresARE-binding proteins that could interact with the exosome andrecruit it to unstable mRNAs, thereby promoting their rapiddegradation. |
| Further Information: | This EXOSC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-38 amino acids from the N-terminal region of human EXOSC6. |
| Synonym: | Exosome complex component MTR3, Exosome component 6, mRNA transport regulator 3 homolog, hMtr3, p11, EXOSC6, MTR3 |
| Ascension Number: | Q5RKV6 |
| NCBI EntrezGene: | 118460 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
