| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) producescGMP following the binding of either endogenous ligands orheat-stable enterotoxins secreted by E. coli and other entericbacteria. Activation of GCC initiates a signaling cascade thatleads to phosphorylation of the cystic fibrosis transmembraneconductance regulator (CFTR; MIM 602421), followed by a net effluxof ions and water into the intestinal lumen. IKEPP is a regulatoryprotein that associates with GCC and regulates the amount of cGMPproduced following receptor stimulation (Scott et al., 2002 [PubMed11950846]). |
| Further Information: | This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3. |
| Synonym: | Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2 |
| Ascension Number: | Q86UT5 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
