| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | DAD1, the defender against apoptotic cell death, wasinitially identified as a negative regulator of programmed celldeath in the temperature sensitive tsBN7 cell line. The DAD1protein disappeared in temperature-sensitive cells following ashift to the nonpermissive temperature, suggesting that loss of theDAD1 protein triggered apoptosis. DAD1 is believed to be a tightlyassociated subunit of oligosaccharyltransferase both in the intactmembrane and in the purified enzyme, thus reflecting the essentialnature of N-linked glycosylation in eukaryotes. [provided byRefSeq]. |
| Further Information: | This DAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human DAD1. |
| Synonym: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, Oligosaccharyl transferase subunit DAD1, Defender against cell death 1, DAD-1, DAD1 |
| Ascension Number: | P61803 |
| NCBI EntrezGene: | 1603 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
