| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a family member of actin-relatedproteins (ARPs), which share significant amino acid sequenceidentity to conventional actins. Both actins and ARPs have an actinfold, which is an ATP-binding cleft, as a common feature. The ARPsare involved in diverse cellular processes, including vesiculartransport, spindle orientation, nuclear migration and chromatinremodeling. This gene encodes a 53 kDa subunit protein of the BAF(BRG1/brm-associated factor) complex in mammals, which isfunctionally related to SWI/SNF complex in S. cerevisiae andDrosophila; the latter is thought to facilitate transcriptionalactivation of specific genes by antagonizing chromatin-mediatedtranscriptional repression. Together with beta-actin, it isrequired for maximal ATPase activity of BRG1, and for theassociation of the BAF complex with chromatin/matrix. Threetranscript variants that encode two different protein isoforms havebeen described. |
| Further Information: | This ACTL6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human ACTL6A. |
| Synonym: | Actin-like protein 6A, 53 kDa BRG1-associated factor A, Actin-related protein Baf53a, ArpNbeta, BRG1-associated factor 53A, BAF53A, INO80 complex subunit K, ACTL6A, BAF53, BAF53A, INO80K |
| Ascension Number: | O96019 |
| NCBI EntrezGene: | 86 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
