| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a member of a superfamily of proteinscomposed predominantly of tandemly arrayed short consensus repeatsof approximately 60 amino acids. A single, unique beta-chainencoded by this gene assembles with seven identical alpha-chainsinto the predominant isoform of C4b-binding protein, a multimericprotein that controls activation of the complement cascade throughthe classical pathway. C4b-binding protein has a regulatory role inthe coagulation system also, mediated through the beta-chainbinding of protein S, a vitamin K-dependent protein that serves asa cofactor of activated protein C. The genes encoding both alphaand beta chains are located adjacent to each other on humanchromosome 1 in the regulator of complement activation genecluster. Alternative splicing gives rise to multiple transcriptvariants. |
| Further Information: | This C4BPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB. |
| Synonym: | C4b-binding protein beta chain, C4BPB |
| Ascension Number: | P20851 |
| NCBI EntrezGene: | 725 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
