| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,elicits a wide array of physiological effects by binding to severalreceptor subtypes, including the 5-HT2 family ofseven-transmembrane-spanning, G-protein-coupled receptors, whichactivate phospholipase C and D signaling pathways. This geneencodes the 2C subtype of serotonin receptor and its mRNA issubject to multiple RNA editing events, where genomically encodedadenosine residues are converted to inosines. RNA editing ispredicted to alter amino acids within the second intracellular loopof the 5-HT2C receptor and generate receptor isoforms that differin their ability to interact with G proteins and the activation ofphospholipase C and D signaling cascades, thus modulatingserotonergic neurotransmission in the central nervous system.Studies in humans have reported abnormalities in patterns of 5-HT2Cediting in depressed suicide victims. |
| Further Information: | This HTR2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human HTR2C. |
| Synonym: | 5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C, HTR2C, HTR1C |
| Ascension Number: | P28335 |
| NCBI EntrezGene: | 3358 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
