| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Activins are dimeric growth and differentiation factorswhich belong to the transforming growth factor-beta (TGF-beta)superfamily of structurally related signaling proteins. Activinssignal through a heteromeric complex of receptor serine kinaseswhich include at least two type I ( I and IB) and two type II (IIand IIB) receptors. These receptors are all transmembrane proteins,composed of a ligand-binding extracellular domain withcysteine-rich region, a transmembrane domain, and a cytoplasmicdomain with predicted serine/threonine specificity. Type Ireceptors are essential for signaling; and type II receptors arerequired for binding ligands and for expression of type Ireceptors. Type I and II receptors form a stable complex afterligand binding, resulting in phosphorylation of type I receptors bytype II receptors. This gene encodes activin A type I receptorwhich signals a particular transcriptional response in concert withactivin type II receptors. Mutations in this gene are associatedwith fibrodysplasia ossificans progressive. |
| Further Information: | This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from the Central region of human ACVR1. |
| Synonym: | Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2 |
| Ascension Number: | Q04771 |
| NCBI EntrezGene: | 90 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
