Ordering Details
Cat Number:	AP13707A
Size:	400uL
Price:	£304.00
Quantity:
Shipping:	£12.00

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Data Sheet

MSDS

FOLH1 [N-term] [RB33647], Rabbit Polyclonal Antibody

Partner: Abcepta, Inc.

Applications:	IF, IHC-P, WB
Species Reactivity:	Human
Isotype:	Rabbit Ig
Purification:	Affinity Purified Rabbit Polyclonal Antibody
Description:	This gene encodes a type II transmembrane glycoproteinbelonging to the M28 peptidase family. The protein acts as aglutamate carboxypeptidase on different alternative substrates,including the nutrient folate and the neuropeptideN-acetyl-l-aspartyl-l-glutamate and is expressed in a number oftissues such as prostate, central and peripheral nervous system andkidney. A mutation in this gene may be associated with impairedintestinal absorption of dietary folates, resulting in low bloodfolate levels and consequent hyperhomocysteinemia. Expression ofthis protein in the brain may be involved in a number ofpathological conditions associated with glutamate excitotoxicity.In the prostate the protein is up-regulated in cancerous cells andis used as an effective diagnostic and prognostic indicator ofprostate cancer. This gene likely arose from a duplication event ofa nearby chromosomal region. Alternative splicing gives rise tomultiple transcript variants encoding several different isoforms.
Further Information:	This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the N-terminal region of human FOLH1.
Synonym:	Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, FOLH1, FOLH, NAALAD1, PSM, PSMA
Ascension Number:	Q04609
NCBI EntrezGene:	2346
Shipping Conditions:	Ship on cold packs
Storage:	Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:	Research use only

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Confocal immunofluorescent analysis of FOLH1 Antibody (N-term)(Cat#AP13707a) with ZR-75-1 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).