Ordering Details
Cat Number:	AP13689c
Size:	400uL
Price:	£304.00
Quantity:
Shipping:	£12.00

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Data Sheet

MSDS

APP [Centre] [RB33592], Rabbit Polyclonal Antibody

Partner: Abcepta, Inc.

Applications:	IHC-P, IF, WB
Species Reactivity:	Human
Isotype:	Rabbit IgG
Purification:	Affinity Purified Rabbit Polyclonal Antibody
Description:	This gene encodes a cell surface receptor andtransmembrane precursor protein that is cleaved by secretases toform a number of peptides. Some of these peptides are secreted andcan bind to the acetyltransferase complex APBB1/TIP60 to promotetranscriptional activation, while others form the protein basis ofthe amyloid plaques found in the brains of patients with Alzheimerdisease. Mutations in this gene have been implicated in autosomaldominant Alzheimer disease and cerebroarterial amyloidosis(cerebral amyloid angiopathy). Multiple transcript variantsencoding several different isoforms have been found for this gene.
Further Information:	This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-362 amino acids from the Central region of human APP.
Synonym:	Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1
Ascension Number:	P05067
NCBI EntrezGene:	351
Shipping Conditions:	Ship on cold packs
Storage:	Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:	Research use only

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Confocal immunofluorescent analysis of APP Antibody (Center)(Cat#AP13689c) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).