| Description: | This gene encodes a multifunctional proinflammatorycytokine that belongs to the tumor necrosis factor (TNF)superfamily. This cytokine is mainly secreted by macrophages. Itcan bind to, and thus functions through its receptorsTNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in theregulation of a wide spectrum of biological processes includingcell proliferation, differentiation, apoptosis, lipid metabolism,and coagulation. This cytokine has been implicated in a variety ofdiseases, including autoimmune diseases, insulin resistance, andcancer. Knockout studies in mice also suggested the neuroprotectivefunction of this cytokine. |
| Synonym: | Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Tumor necrosis factor, membrane form, N-terminal fragment, NTF, Intracellular domain 1, ICD1, Intracellular domain 2, ICD2, C-domain 1, C-domain 2, Tumor necrosis factor, soluble form, TNF, TNFA, TNFSF2 |
