| Applications: | IHC-P, WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | The giant protein titin, together with its associatedproteins, interconnects the major structure of sarcomeres, the Mbands and Z discs. The C-terminal end of the titin string extendsinto the M line, where it binds tightly to M-band constituents ofapparent molecular masses of 190 kD (myomesin 1) and 165 kD(myomesin 2). This protein, myomesin 1, like myomesin 2, titin, andother myofibrillar proteins contains structural modules with stronghomology to either fibronectin type III (motif I) or immunoglobulinC2 (motif II) domains. Myomesin 1 and myomesin 2 each have a uniqueN-terminal region followed by 12 modules of motif I or motif II, inthe arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteinsshare 50% sequence identity in this repeat-containing region. Thehead structure formed by these 2 proteins on one end of the titinstring extends into the center of the M band. The integratingstructure of the sarcomere arises from muscle-specific members ofthe superfamily of immunoglobulin-like proteins. Alternativelyspliced transcript variants encoding different isoforms have beenidentified. |
| Further Information: | This MYOM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 904-933 amino acids from the Central region of human MYOM1. |
| Synonym: | Myomesin-1, 190 kDa connectin-associated protein, 190 kDa titin-associated protein, Myomesin family member 1, MYOM1 |
| Ascension Number: | P52179 |
| NCBI EntrezGene: | 8736 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
