| Applications: | IHC-P, IF, WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene was identified as a tumor suppressor that ismutated in a large number of cancers at high frequency. The proteinencoded this gene is a phosphatidylinositol-3,4,5-trisphosphate3-phosphatase. It contains a tensin like domain as well as acatalytic domain similar to that of the dual specificity proteintyrosine phosphatases. Unlike most of the protein tyrosinephosphatases, this protein preferentially dephosphorylatesphosphoinositide substrates. It negatively regulates intracellularlevels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKBsignaling pathway. |
| Further Information: | This PTEN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-335 amino acids from the C-terminal region of human PTEN. |
| Synonym: | Phosphatidylinositol 3,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1 |
| Ascension Number: | P60484 |
| NCBI EntrezGene: | 5728 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
