Applications: | IHC-P, WB |
Species Reactivity: | Human |
Isotype: | Rabbit Ig |
Purification: | Affinity Purified Rabbit Polyclonal Antibody |
Description: | This gene is a member of the protocadherin alpha genecluster, one of three related gene clusters tandemly linked onchromosome five that demonstrate an unusual genomic organizationsimilar to that of B-cell and T-cell receptor gene clusters. Thealpha gene cluster is composed of 15 cadherin superfamily genesrelated to the mouse CNR genes and consists of 13 highly similarand 2 more distantly related coding sequences. The tandem array of15 N-terminal exons, or variable exons, are followed by downstreamC-terminal exons, or constant exons, which are shared by all genesin the cluster. The large, uninterrupted N-terminal exons eachencode six cadherin ectodomains while the C-terminal exons encodethe cytoplasmic domain. These neural cadherin-like cell adhesionproteins are integral plasma membrane proteins that most likelyplay a critical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beenobserved and additional variants have been suggested but theirfull-length nature has yet to be determined. |
Further Information: | This PCDHA12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the N-terminal region of human PCDHA12. |
Synonym: | Protocadherin alpha-12, PCDH-alpha-12, PCDHA12 |
Ascension Number: | Q9UN75 |
NCBI EntrezGene: | 56137 |
Shipping Conditions: | Ship on cold packs |
Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
Usage: | Research use only |