| Applications: | FC, WB |
| Species Reactivity: | Mouse |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Peroxisome proliferators include hypolipidemic drugs,herbicides, leukotriene antagonists, and plasticizers; this termarises because they induce an increase in the size and number ofperoxisomes. Peroxisomes are subcellular organelles found in plantsand animals that contain enzymes for respiration and forcholesterol and lipid metabolism. The action of peroxisomeproliferators is thought to be mediated via specific receptors,called PPARs, which belong to the steroid hormone receptorsuperfamily. PPARs affect the expression of target genes involvedin cell proliferation, cell differentiation and in immune andinflammation responses. Three closely related subtypes (alpha,beta/delta, and gamma) have been identified. This gene encodes thesubtype PPAR-alpha, which is a nuclear transcription factor.Multiple alternatively spliced transcript variants have beendescribed for this gene, although the full-length nature of onlytwo has been determined. |
| Further Information: | This PPARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-181 amino acids from the Central region of human PPARA. |
| Synonym: | Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR |
| Ascension Number: | Q07869 |
| NCBI EntrezGene: | 5465 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
