| Applications: | WB |
| Species Reactivity: | Mouse |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a transcription factor that regulatesMHC class II genes by binding to a promoter element referred to asan X box. This gene product is a bZIP protein, which was alsoidentified as a cellular transcription factor that binds to anenhancer in the promoter of the T cell leukemia virus type 1promoter. It may increase expression of viral proteins by acting asthe DNA binding partner of a viral transactivator. It has beenfound that upon accumulation of unfolded proteins in theendoplasmic reticulum (ER), the mRNA of this gene is processed toan active form by an unconventional splicing mechanism that ismediated by the endonuclease inositol-requiring enzyme 1 (IRE1).The resulting loss of 26 nt from the spliced mRNA causes aframe-shift and an isoform XBP1(S), which is the functionallyactive transcription factor. The isoform encoded by the unsplicedmRNA, XBP1(U), is constitutively expressed, and thought to functionas a negative feedback regulator of XBP1(S), which shuts offtranscription of target genes during the recovery phase of ERstress. A pseudogene of XBP1 has been identified and localized tochromosome 5. |
| Further Information: | This XBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 amino acids from the C-terminal region of human XBP1. |
| Synonym: | X-box-binding protein 1, XBP-1, Tax-responsive element-binding protein 5, XBP1, TREB5, XBP2 |
| Ascension Number: | P17861 |
| NCBI EntrezGene: | 7494 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
