| Applications: | FC, IF, IHC-P, WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene lies adjacent to the tumor suppressor geneCDKN2A in a region that is frequently mutated and deleted in a widevariety of tumors. This gene encodes a cyclin-dependent kinaseinhibitor, which forms a complex with CDK4 or CDK6, and preventsthe activation of the CDK kinases, thus the encoded proteinfunctions as a cell growth regulator that controls cell cycle G1progression. The expression of this gene was found to bedramatically induced by TGF beta, which suggested its role in theTGF beta induced growth inhibition. Two alternatively splicedtranscript variants of this gene, which encode distinct proteins,have been reported. |
| Further Information: | This CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human CDKN2B. |
| Synonym: | Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, MTS-2, p14-INK4b, p15-INK4b, p15INK4B, CDKN2B, MTS2 |
| Ascension Number: | P42772 |
| NCBI EntrezGene: | 1030 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
