| Applications: | WB, IHC-P |
| Species Reactivity: | Human, Rat |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Pyruvate dehydrogenase (E1) is one of the three components(E1, E2, and E3) of the large pyruvate dehydrogenase complex.Pyruvate dehydrogenase kinases catalyze phosphorylation of serineresidues of E1 to inactivate the E1 component and inhibit thecomplex. Pyruvate dehydrogenase phosphatases catalyze thedephosphorylation and activation of the E1 component to reverse theeffects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenasephosphatase is a heterodimer consisting of catalytic and regulatorysubunits. Two catalytic subunits have been reported; one ispredominantly expressed in skeletal muscle and another one is ismuch more abundant in the liver. The catalytic subunit, encoded bythis gene, is the former, and belongs to the protein phosphatase 2C(PP2C) superfamily. Along with the pyruvate dehydrogenase complexand pyruvate dehydrogenase kinases, this enzyme is located in themitochondrial matrix. Mutation in this gene causes pyruvatedehydrogenase phosphatase deficiency. Multiple alternativelyspliced transcript variants encoding different isoforms have beenidentified. |
| Further Information: | This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1. |
| Synonym: | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial, PDP 1, Protein phosphatase 2C, Pyruvate dehydrogenase phosphatase catalytic subunit 1, PDPC 1, PDP1, PDP, PPM2C |
| Ascension Number: | Q9P0J1 |
| NCBI EntrezGene: | 54704 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
