| Applications: | IHC-P, WB |
| Species Reactivity: | Human, Mouse |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Crystallins are separated into two classes:taxon-specific, or enzyme, and ubiquitous. The latter classconstitutes the major proteins of vertebrate eye lens and maintainsthe transparency and refractive index of the lens. Since lenscentral fiber cells lose their nuclei during development, thesecrystallins are made and then retained throughout life, making themextremely stable proteins. Mammalian lens crystallins are dividedinto alpha, beta, and gamma families; beta and gamma crystallinsare also considered as a superfamily. Alpha and beta families arefurther divided into acidic and basic groups. Seven protein regionsexist in crystallins: four homologous motifs, a connecting peptide,and N- and C-terminal extensions. Beta-crystallins, the mostheterogeneous, differ by the presence of the C-terminal extension(present in the basic group, none in the acidic group).Beta-crystallins form aggregates of different sizes and are able toself-associate to form dimers or to form heterodimers with otherbeta-crystallins. This gene, a beta acidic group member, encodestwo proteins (crystallin, beta A3 and crystallin, beta A1) from asingle mRNA, the latter protein is 17 aa shorter than crystallin,beta A3 and is generated by use of an alternate translationinitiation site. Deletion of exons 3 and 4 causes the autosomaldominant disease 'zonular cataract with sutural opacities'. |
| Further Information: | This CRYBA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the Central region of human CRYBA1. |
| Synonym: | Beta-crystallin A3, Beta-crystallin A3, isoform A1, Delta4 form, Beta-crystallin A3, isoform A1, Delta7 form, Beta-crystallin A3, isoform A1, Delta8 form, CRYBA1, CRYB1 |
| Ascension Number: | P05813 |
| NCBI EntrezGene: | 1411 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
