| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene represents a member of the 'frizzled' genefamily, which encode 7-transmembrane domain proteins that arereceptors for Wnt signaling proteins. The protein encoded by thisfamily member contains a signal peptide, a cysteine-rich domain inthe N-terminal extracellular region, and seven transmembranedomains, but unlike other family members, this protein does notcontain a C-terminal PDZ domain-binding motif. This proteinfunctions as a negative regulator of the canonical Wnt/beta-cateninsignaling cascade, thereby inhibiting the processes that triggeroncogenic transformation, cell proliferation, and inhibition ofapoptosis. Alternative splicing results in multiple transcriptvariants. |
| Further Information: | This FZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6. |
| Synonym: | Frizzled-6, Fz-6, hFz6, FZD6 |
| Ascension Number: | O60353 |
| NCBI EntrezGene: | 8323 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
