| Applications: | WB |
| Species Reactivity: | Human, Mouse |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
| Further Information: | This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1. |
| Synonym: | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, AGAP-2, Centaurin-gamma-1, Cnt-g1, GTP-binding and GTPase-activating protein 2, GGAP2, Phosphatidylinositol 3-kinase enhancer, PIKE, AGAP2, CENTG1, KIAA0167 |
| Ascension Number: | Q99490 |
| NCBI EntrezGene: | 116986 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
