Ordering Details
Cat Number:	AM8622b
Size:	200uL
Price:	£304.00
Quantity:
Shipping:	£12.00

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Data Sheet

MSDS

MBD2 [1812CT625.9.45], Mouse Monoclonal Antibody

Partner: Abcepta, Inc.

Applications:	WB, IHC-P
Species Reactivity:	Human
Isotype:	IgG1,k
Purification:	Purified Mouse Monoclonal Antibody
Description:	Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Further Information:	This MBD2 antibody is generated from a mouse immunized with a recombinant protein between 10-228 amino acids from human MBD2.
Synonym:	Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2, MBD2
Ascension Number:	Q9UBB5
NCBI EntrezGene:	8932
Shipping Conditions:	Ship on cold packs
Storage:	Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:	Research use only

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All lanes : Anti-MBD2 Antibody at 1:2000 dilutionLane 1: K562 whole cell lysateLane 2: MCF-7 whole cell lysateLane 3: Jurkat whole cell lysateLysates/proteins at 20 �g per lane. SecondaryGoat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 43 kDaBlocking/Dilution buffer: 5% NFDM/TBST.