| Applications: | WB, FC, IHC-P-Leica |
| Species Reactivity: | Human |
| Isotype: | IgG1,k |
| Purification: | Purified Mouse Monoclonal Antibody |
| Description: | Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:<a href=http://www.uniprot.org/citations/15283675 target=_blank>15283675</a>, PubMed:<a href=http://www.uniprot.org/citations/8168535 target=_blank>8168535</a>). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:<a href=http://www.uniprot.org/citations/17101991 target=_blank>17101991</a>). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:<a href=http://www.uniprot.org/citations/15283675 target=_blank>15283675</a>). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:<a href=http://www.uniprot.org/citations/2531377 target=_blank>2531377</a>, PubMed:<a href=http://www.uniprot.org/citations/2972276 target=_blank>2972276</a>). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:<a href=http://www.uniprot.org/citations/20876573 target=_blank>20876573</a>). |
| Further Information: | This MME antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 472-505 amino acids from the Central region of human MME. |
| Synonym: | Neprilysin, 3.4.24.11, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 24.11, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN |
| Ascension Number: | P08473 |
| NCBI EntrezGene: | 4311 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
